All products have special prices for bulk purchase, please contact for more details if required.

Cat. No.: PSRL-0.2 (for 10mM×0.2ml)

Cat. No.: PSRL-25 (for 25mg)

Cat. No.: PSRL-100 (for 100mg)

Description

Psoralen (Ficusin) is a coumarin compound isolated from the seeds of Fructus Psoraleae. It possesses a diverse array of biological properties, including anti-cancer, antioxidant, antidepressant, antibacterial, antiviral, and more.

Basic Information

• Aliases: Ficusin
• Source: Psoralea corylifolia Linn.
• Compound type: Phenylpropanoids > Coumarins > Linear Furanocoumarins
• Chemical Formula: C₁₁H₆O₃
• Molecular Weight: 186.16
• CAS Number: 66-97-7
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 25 mg/mL (134.29 mM); Water: 1 mg/mL (5.37 mM; ultrasonic and warming and heat to 80°C)
• Solution Preparation: Add 2 mg to 1.07 mL of DMSO, or add 1.86 mg to 1 mL of DMSO to prepare a 10 mM solution.

Signaling Pathway

Apoptosis

In Vitro Study

Psoralen (10-500 μM; 24-48 hours) exhibits a concentration- and time-dependent inhibition of cell viability in L02 and HepG2 cells. In L02 cells, Psoralen at 400 μM shows no significant alteration in extracellular LDH levels, while 400 μM or 450 μM psoralen inhibits 50–60% of cell viability. Psoralen (150-450 μM; 24 hours) induces significant S-phase arrest in L02 cells in a time- and dose-dependent manner, but it does not result in a significant change in the cell cycle distribution of HepG2 cells.

In Vivo Study

Psoralen (oral gavage; 17.5 mg/kg; 6 weeks) administration reduces the number of metastatic lesions and the rate of bone metastasis by 20% compared to vehicle-treated mice. Additionally, it diminishes tumor infiltration and lowers the percentage of tumor cells in metastatic lesions by approximately 40% compared to the vehicle in mice.

Clinical Trial

NCT00217009: Dermatitis|Psoriasis, Phase 1; NCT00005092: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes, Phase 1.

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

Journals Using SBS Genetech Products                                       Universities Using SBS Genetech Products

SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory