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Cat. No.: NHSD-0.2 (for 10mM×0.2ml)

Cat. No.: NHSD-25 (for 25mg)

Cat. No.: NHSD-100 (for 100mg)

Description

Neohesperidin is a flavonoid compound abundant in Poncirus trifoliata, known for its potent antioxidant and anti-inflammatory properties.

Basic Information

• Aliases: Hesperetin 7-neohesperidoside
• Source: Citrus reticulata Blanco; Citrus aurantium L.
• Compound type: Flavonoids > Dihydroflavones
• Chemical Formula: C₂₈H₃₄O₁₅
• Molecular Weight: 610.56
• CAS Number: 13241-33-3
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 100 mg/ml (163.78 mM)
• Solution Preparation: 10mg added to 1.64ml of DMSO, or 6.11mg added to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

In Vitro Study

Neohesperidin induces apoptosis in human breast adenocarcinoma MDA-MB-231 cells. The IC50 values of neohesperidin at 24 and 48 hours are 47.4±2.6 μM and 32.5±1.8 μM, respectively. Treatment with neohesperidin significantly up-regulates the expressions of P53 and Bax, while down-regulating that of Bcl-2 in the treated cells. Additionally, neohesperidin exhibits antioxidant activity with an IC50 value of 22.31 μg/ml in the DPPH radical-scavenging assay.

In Vivo Study

Neohesperidin administered at a dose of 50 mg/kg significantly inhibits 55.0% of HCl/ethanol-induced gastric lesions. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly reduces the volume of gastric secretion and gastric acid output, while increasing the pH levels. Treatment with neohesperidin significantly lowers fasting glucose, serum glucose, and glycosylated serum protein (GSP) levels in mice. Furthermore, it markedly improves oral glucose tolerance and insulin sensitivity, while decreasing insulin resistance in diabetic mice. Neohesperidin also reduces serum triglycerides, total cholesterol, leptin levels, and liver index in these mice.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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