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Cat. No.: MGZMBH-10 (for 10μg)

Cat. No.: MGZMBH-25 (for 25μg)

Cat. No.: MGZMBH-50 (for 50μg)

Cat. No.: MGZMBH-100 (for 100μg)

Description

Granzyme B (GZMB) is one of the serine protease granzymes most commonly found in the granules of natural killer (NK) cells and cytotoxic T cells. These cells secrete granzyme B along with the pore-forming protein perforin to mediate apoptosis in target cells. Granzyme B is also produced by a wide range of non-cytotoxic cells, including basophils, mast cells, and smooth muscle cells. Besides its primary role in inducing apoptosis, granzyme B has several secondary functions. It is involved in inducing inflammation by stimulating cytokine release and plays a role in extracellular matrix remodeling.

Species

Mouse

Molecular Alias

Granzyme B, CTLA-1, Cytotoxic cell protease 1 (CCP1), Fragmentin-2

Accession

P04187

Expression Sequence

Protein sequence(P04187, Lys17-Ser247, with C-10*His)

KAGEIIGGHEVKPHSRPYMALLSIKDQQPEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTLQEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVSYGYKDGSPPRAFTKVSSFLSWIKKTMKSSGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 27.4kDa 

Actual: 31kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, stored at -20 to -70 °C as supplied.

6 months at -20 to -70 °C under sterile conditions after reconstitution.

1 week at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.