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Cat. No.: MCAIXH-25 (for 25μg)

Cat. No.: MCAIXH-50 (for 50μg)

Cat. No.: MCAIXH-100 (for 100μg)

Description

Carbonic anhydrase IX (CA9/CAIX) is one of the 14 carbonic anhydrase isoforms found in humans. It is a transmembrane dimeric metalloenzyme with an extracellular active site that facilitates acid secretion in the gastrointestinal tract. CAIX is overexpressed in many types of cancer, including clear cell renal cell carcinoma (RCC) and carcinomas of the cervix, breast, and lung. Its overexpression promotes tumor growth by enhancing tumor acidosis.

Species

Mouse

Molecular Alias

Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX), Membrane antigen MN homolog, Ca9, Car9

Accession

Q8VHB5

Expression Sequence

Protein sequence(Q8VHB5, Ser118-Asp390, with C-10*His)

SHWSYGGTLLWPQVSPACAGRFQSPVDIRLERTAFCRTLQPLELLGYELQPLPELSLSNNGHTVQLTLPPGLKMALGPGQEYRALQLHLHWGTSDHPGSEHTVNGHRFPAEIHVVHLSTAFSELHEALGRPGGLAVLAAFLQESPEENSAYEQLLSHLEEISEEGSKIEIPGLDVSALLPSDLSRYYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQLHTLSVSLWGPRDSRLQLNFRATQPLNGRTIEASFPAAEDSSPEPVHVNSCFTAGDGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 31.6kDa 

Actual: 34kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt when stored at -20 to -70 °C as supplied.

6 months at -20 to -70 °C under sterile conditions after reconstitution.

1 week at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.