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Description

Agomir is a double-stranded small RNA that is specially labeled and chemically modified to mimic endogenous miRNAs, thereby regulating the biological functions of target genes. Leveraging our advanced nucleic acid chemical synthesis technology, we have developed an upgraded product of miRNA mimics, the miRNA agomir. We offer you a more cost-effective experimental solution, easier experimental operation, and more perfect experimental results.

Features

• Compared to regular mimics, agomir has higher affinity for cell membranes, significantly reducing the amount of transfection reagent needed in cell transfection experiments.
• It is particularly suitable for in vivo interference experiments and exhibits higher stability and inhibition effects in vivo. It can be administered in various ways, such as systemic injection or local injection, with simple operation.
• It can be enriched in target cells, achieving efficient and specific stable interference.
• The inhibition duration is long, lasting at least one week, with interference effects lasting up to 5-6 weeks.

Chemical Modification Structure

The antisense strand of agomir is modified, with cholesterol modification at the 3' end, two thiophosphate modifications at the 5' end, four thiophosphate modifications at the 3' end, and full-chain methoxy modifications.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory