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Cat. No.: MGNL-0.2 (for 10mM×0.2ml)

Cat. No.: MGNL-25 (for 25mg)

Cat. No.: MGNL-100 (for 100mg)

Description

Magnolol, a natural lignan extracted from the stem bark of Magnolia officinalis, serves as a dual agonist for RXRα and PPARγ, exhibiting EC50 values of 10.4 µM and 17.7 µM, respectively.

Basic Information

• Aliases: 5,5'-Diallyl-2,2'-biphenyldiol
• Source: Magnolia officinalis Rehd. et Wils.
• Compound type: Phenylpropanoids > Lignans > Other Lignans
• Chemical Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.33
• CAS Number: 528-43-8
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 100 mg/ml (375.47 mM)
• Solution Preparation: Add 5mg to 1.88ml of DMSO, or alternatively, add 2.66mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

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In Vitro Study

Magnolol acts as a dual agonist for both RXRα and PPARγ, displaying EC50 values of 10.4 µM and 17.7 µM, respectively. Moreover, Magnolol (at concentrations ranging from 26.2 to 80 µM) binds to RXRαLBD and PPARγLBD in a dose-dependent manner, with Kd values of 45.7 µM and 1.67 µM, respectively. In addition, Magnolol (at concentrations from 1 to 20 µM) induces PPRE transcription in a dose-dependent manner but exhibits no activity on RXRE transcription. Furthermore, Magnolol (at concentrations of 1, 3, and 10 µM) enhances adipocyte differentiation in both 3T3-L1 pre-adipocytes and C3H10T1/2 pluripotent stem cells in the presence of insulin. Magnolol (at 10 μM) also upregulates mRNA expression of marker genes for adipocyte differentiation. Additionally, Magnolol (at concentrations of 1 and 10 μM) enhances basal and insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes.

In Vivo Study

Magnolol, administered orally at doses ranging from 5 to 15 mg/kg, significantly mitigates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Specifically, doses of 10 and 15 mg/kg orally administered attenuate histopathological changes and myeloperoxidase activity in the colons of DSS-treated mice. Furthermore, these doses decrease the elevated levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6 in colonic tissues induced by DSS. Additionally, at a dose of 10 mg/kg administered orally, Magnolol reverses abnormalities in serum metabolome and regulates the tryptophan metabolic pathway in mice.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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