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Cat. No.: MGNL-0.2 (for 10mM×0.2ml)

Cat. No.: MGNL-5 (for 5mg)

Cat. No.: MGNL-25 (for 25mg)

Cat. No.: MGNL-100 (for 100mg)

Description

Magnolin, a primary constituent of Magnolia flos (Shin-Yi), targets the active pocket of ERK1 and ERK2, inhibiting the Ras/ERKs/RSK2 signaling axis with IC50 values of 87 nM and 16.5 nM, respectively.

Basic Information

• Aliases: -
• Source: Magnolia liliflora Desr
• Compound type: Phenylpropanoids > Lignans > Dibenzylbutyrolactone Lignans
• Chemical Formula: C₂₃H₂₈O₇
• Molecular Weight: 416.46
• CAS Number: 31008-18-1
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 100 mg/ml (240.12 mM)
• Solution Preparation: Add 5mg to 1.20ml of DMSO, or alternatively, add 4.16mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

-

In Vitro Study

Magnolin, a natural compound abundant in Magnolia flos, has long been utilized in oriental medicine to alleviate headaches, nasal congestion, and inflammatory reactions. It specifically targets the active pockets of ERK1 and ERK2, pivotal signaling molecules in cancer cell metastasis. By suppressing the ERKs/RSK2 signaling pathway, Magnolin effectively inhibits NF-κB transactivation activity. Additionally, it curtails the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) through the inhibition of extracellular signal-regulated kinases (ERKs), crucial in regulating cell proliferation, transformation, and cancer cell metastasis. Notably, Magnolin treatment significantly suppresses JB6 Cl41 cell migration induced by EGF treatment in a dose-dependent manner. Furthermore, Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, thereby inhibiting NF-κB activation and subsequent cell migration.

In Vivo Study

N/A

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory