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Cat. No.: HTBPH-25 (for 25μg)

Cat. No.: HTBPH-50 (for 50μg)

Cat. No.: HTBPH-100 (for 100μg)

Description

Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein encoded by the THPO gene in humans. This glycoprotein hormone is produced by the liver and kidneys and plays a crucial role in regulating platelet production. Thrombopoietin stimulates the production and differentiation of megakaryocytes, the bone marrow cells responsible for generating large numbers of platelets. Megakaryocytopoiesis, the process of cellular development leading to platelet production, depends on thrombopoietin as a vital humoral growth factor for megakaryocyte proliferation, maturation, and subsequent thrombopoiesis.

Species

Human

Molecular Alias

C-mpl ligand (ML), Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor (MGDF), Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF

Accession

P40225

Expression Sequence

Protein sequence(P40225, Ser22-Gly353, with C-10*His)

SPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEGGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical:37.1kDa 

Actual:75-90kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, stored at -20 to -70 °C as supplied.

6 months at -20 to -70 °C under sterile conditions after reconstitution.

1 week at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.