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Cat. No.: HTBMH-25 (for 25μg)

Cat. No.: HTBMH-50 (for 50μg)

Cat. No.: HTBMH-100 (for 100μg)

Description

Thrombomodulin is an endothelial-specific type I membrane receptor that binds thrombin. This binding activates protein C, which degrades clotting factors Va and VIIIa, thereby reducing thrombin generation. Predominantly expressed on the endothelium, thrombomodulin plays a crucial role in maintaining vascular homeostasis by regulating the coagulation system. Mutations in the thrombomodulin gene can cause thromboembolic disease, also known as inherited thrombophilia.

Species

Human

Molecular Alias

TM,Fetomodulin,CD141

Accession

P07204

Expression Sequence

Protein sequence(P07204, Ala19-Thr281, with C-10*His)

APAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 29.1kDa 

Actual: 37kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.