
Human sFlt-1, His tag
$644.00 - $1,148.00
$1,435.00
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Cat. No.: HSF1H-50 (for 50μg)
Cat. No.: HSF1H-100 (for 100μg)
Description
Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties. As a non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds to angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), thereby reducing blood vessel growth by lowering free VEGF and PlGF concentrations. In humans, sFlt-1 plays a crucial role in regulating blood vessel formation in various tissues, including the kidneys, cornea, and uterus. Abnormally high levels of sFlt-1 have been implicated in the pathogenesis of preeclampsia.
Species
Human
Molecular Alias
Soluble fms-like tyrosine kinase 1
Accession
P17948-2
Expression Sequence
Protein sequence(P17948-2, Ser27-His687, with C-10*His)
SKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGEHCNKKAVFSRISKFKSTRNDCTTQSNVKHGGGGSHHHHHHHHHH
Expression Host
HEK293
Molecular Weight
Theoretical: 76.4kDa
Actual: 100kDa
Purity
>95% by SDS-PAGE
Endotoxin content
<1 EU/μg
Label
Unconjugated
Tag
His Tag
Form
Lyophilized Powder
Buffer System
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution Method
Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Storage Conditions
12 months from the date of receipt, at -20 to -70 °C as supplied.
1 month, at 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.