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Cat. No.: HOTPH-10 (for 10μg)

Cat. No.: HOTPH-25 (for 25μg)

Cat. No.: HOTPH-50 (for 50μg)

Cat. No.: HOTPH-100 (for 100μg)

Cat. No.: HOTPH-500 (for 500μg)

Cat. No.: HOTPH-1k (for 1mg)

Description

Osteopontin (OPN) is a protein encoded by the SPP1 gene (secreted phosphoprotein 1) in humans, with the murine ortholog being Spp1. First identified in 1986 in osteoblasts, osteopontin is a SIBLING glycoprotein and an extracellular structural protein, making it a crucial organic component of bone. OPN interacts with multiple ubiquitously expressed cell surface receptors, playing an active role in numerous physiological and pathological processes, including wound healing, bone turnover, tumorigenesis, inflammation, ischemia, and immune responses. Modulating plasma or local OPN levels may be beneficial in treating autoimmune diseases, cancer metastasis, bone and tooth mineralization diseases, osteoporosis, and certain forms of stress.

Species

Human

Molecular Alias

Bone sialoprotein 1, Nephropontin, Secreted phosphoprotein 1 (SPP-1), Urinary stone protein, Uropontin, BNSP, OPN

Accession

P10451

Expression Sequence

Protein sequence (P10451, Ile17-Glu294, with C-10*His)

IPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Predicted MW: 33.1 kDa 

Observed MW: 60 kDa

Purity

＞90% by SDS-PAGE

Tag

with C-10*His

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt when stored at -20 to -70 °C as supplied.

6 months at -20 to -70 °C under sterile conditions after reconstitution.

1 week at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.