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Cat. No.: HLG1H-50 (for 50μg)

Cat. No.: HLG1H-100 (for 100μg)

Description

Laminins are a family of glycoproteins found in the extracellular matrix of all animals. They are major components of the basal lamina, a layer of the basement membrane that serves as a foundational protein network for most cells and organs. Laminins play a crucial role in the basal lamina, influencing cell differentiation, migration, and adhesion. These heterotrimeric proteins, with a high molecular mass ranging from approximately 400 to 900 kDa, consist of three different chains (α, β, and γ), encoded by five, four, and three paralogous genes in humans, respectively.

The laminin family of glycoproteins is integral to the structural scaffolding in almost every tissue of an organism. They are secreted and incorporated into cell-associated extracellular matrices, essential for the maintenance and survival of tissues. Defective laminins can lead to various conditions, including improper muscle formation resulting in a form of muscular dystrophy, lethal skin blistering disease known as junctional epidermolysis bullosa, and defects in the kidney filter, causing nephrotic syndrome.

Species

Human

Molecular Alias

aminin subunit gamma-1, Laminin B2 chain, Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, LAMC1

Accession

P11047

Expression Sequence

Protein sequence(P11047, Gln34-Leu484, with C-10*His)

QAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLGGGGSHHHHHHHHHH

Expression Host

HEK293

Purity

95% by SDS-PAGE

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.