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Cat. No.: HATB3H-25 (for 25μg)

Cat. No.: HATB3H-50 (for 50μg)

Cat. No.: HATB3H-100 (for 100μg)

Description

Antithrombin III is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin and other activated serine proteases in the coagulation system, thereby regulating the blood coagulation cascade. It comprises two functional domains: the heparin-binding domain at the N-terminus and the reactive site domain at the C-terminus. The inhibitory activity of antithrombin III is enhanced by the presence of heparin. Numerous mutations in the gene encoding this protein have been identified, many of which cause antithrombin III deficiency, a significant risk factor for thrombosis. Reduced serum levels of antithrombin III are associated with severe cases of Coronavirus Disease 2019 (COVID-19).

Species

Human

Molecular Alias

ATIII, Serpin C1

Accession

P01008

Expression Sequence

Protein sequence(P01008, His33-Lys464, with C-10*His)

HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVKGGGGSHHHHHHHHHH

Expression Host

HEK293

Molecular Weight

Theoretical: 50.7kDa 

Actual: 65kDa

Purity

＞95% by SDS-PAGE

Endotoxin content

<1 EU/μg

Label

Unconjugated

Tag

His Tag

Form

Lyophilized Powder

Buffer System

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

Reconstitution Method

Reconstitute at no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

Storage Conditions

12 months from the date of receipt, at -20 to -70 °C as supplied.

1 month, at 2 to 8 °C under sterile conditions after reconstitution.

Please avoid repeated freeze-thaw cycles.