All products have special prices for bulk purchase, please contact for more details if required.

Cat. No.: HSRD-0.2 (for 10mM×0.2ml)

Cat. No.: HSRD-25 (for 25mg)

Cat. No.: HSRD-100 (for 100mg)

Description

Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is derived from citrus fruits. It boasts a plethora of biological properties, including the reduction of inflammatory mediators and notable antioxidant effects. Moreover, Hesperidin showcases antitumor and antiallergic activities.

Basic Information

• Aliases: Hesperetin 7-rutinoside
• Source: Citrus medica L. var. sarcodactylis Swingle; Citrus reticulata Blanco
• Compound type: Flavonoids > Flavones > Dihydroflavones
• Chemical Formula: C₂₈H₃₄O₁₅
• Molecular Weight: 610.56
• CAS Number: 520-26-3
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: ≥ 33 mg/ml (54.05 mM)
• Solution Preparation: 10mg dissolved in 1.64ml DMSO, or alternatively, 6.11mg dissolved in 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

In Vitro Study

Hesperidin (5-200 µM; 24-72 h) exhibits potent cytotoxic effects on human osteosarcoma MG-63 cells. Treatment with Hesperidin (5-150 µM; 48 h) induces both early and late apoptosis in MG-63 cells. In RAW 264.7 cells activated with LPS, Hesperidin (10-30 µM) dose-dependently inhibits the activity of COX-2 and iNOS. Moreover, Hesperidin (0.1 μg/ml; 2 h) reduces the formation of MDA and intracellular ROS, thereby decreasing chondrocyte apoptosis.

In Vivo Study

Hesperidin (5-80 mg/kg; 2 weeks) demonstrates significant suppression of MG-63 tumor growth in mice. Additionally, Hesperidin (200 mg/kg; once daily for 28 days) markedly attenuates cartilage destruction and reduces IL-1β and TNF-α levels in rats with surgically-induced osteoarthritis (OA).

Clinical Trial

NCT04358497: Pelvic Congestive Syndrome|Pelvic Varices|Venous Disease, Phase 4; NCT03471910: Venous Insufficiency, Phase 4.

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

Journals Using SBS Genetech Products                                       Universities Using SBS Genetech Products

SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory