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Cat. No.: FSSB-0.2 (for 10mM×0.2ml)

Cat. No.: FSSB-5 (for 5mg)

Cat. No.: FSSB-25 (for 25mg)

Cat. No.: FSSB-100 (for 100mg)

Description

Forsythoside B, a phenylethanoid glycoside extracted from the leaves of Lamiophlomis rotata Kudo, a traditional Chinese medicinal plant used for treating inflammatory conditions and improving blood circulation. Forsythoside B demonstrates inhibitory effects on TNF-alpha, IL-6, and IκB, while also modulating NF-κB signaling.

Basic Information

• Aliases: -
• Source: Forsythia suspensa (Thunb.) Vahl
• Compound type: Phenylpropanoids > Phenylpropanoic acids
• Chemical Formula: C₃₄H₄₄O₁₉
• Molecular Weight: 756.7
• CAS Number: 81525-13-5
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 125 mg/ml (165.19 mM); Water: 110 mg/ml (145.37 mM)
• Solution Preparation: Add 10mg to 1.32ml of DMSO, or add 7.57mg to 1ml of DMSO, to prepare a 10mM solution.

Signaling Pathway

IKK

In Vitro Study

Forsythoside B exhibits a concentration-dependent reduction in the levels of TNF-α, IL-6, and high-mobility group-box 1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. It also inhibits the IκB kinase (IKK) pathway and modulates the activity of nuclear factor (NF)-κB.

In Vivo Study

Intravenous injection of forsythoside B, either alone or in combination with imipenem, leads to a reduction in serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1), and endotoxin. Additionally, it upregulates the serum level of IL-10 while reducing myeloperoxidase (MPO) levels in the lung, liver, and small intestine.

At doses exceeding 8 mg/kg, forsythoside B demonstrates significant neuroprotective potential in rats subjected to cerebral ischemia and reperfusion. Even when administered with delays of 1 hour, 3 hours, or 5 hours after cerebral ischemia and reperfusion, forsythoside B at a dosage of 20 mg/kg exhibits noteworthy neuroprotective activity. This is evidenced by its ability to attenuate histopathological damage, including a reduction in brain infarct size, brain edema, cerebral Evans blue extravasation, and myeloperoxidase activity, as well as inhibition of cerebral phosphor-IκB-α and NF-κB expression.

Moreover, forsythoside B demonstrates significant improvement in myocardial function, characterized by enhanced left ventricular systolic pressure (LVSP) and +/- dp/dt(max). It reduces myocardial infarct volume, serum levels of Tn-T, TNF-alpha, and IL-6, as well as the content of malondialdehyde (MDA) and MPO activity in myocardial tissue. Additionally, it downregulates protein expression of HMGB1, phosphor-IκB-α, and phosphor-NF-κB, while attenuating the decrease in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities.

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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