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Cat. No.: CRSN-0.2 (for 10mM×0.2ml)

Cat. No.: CRSN-25 (for 25mg)

Cat. No.: CRSN-100 (for 100mg)

Description

Chrysin is renowned as one of the most effective estrogen blockers.

Basic Information

• Aliases: 5,7-Dihydroxyflavone; Chrysinic acid
• Source: Apis mellifera L.; Oroxylum indicum (Linn.) Kurz
• Compound type: Flavonoids > Flavones
• Chemical Formula: C₁₅H₁₀O₄
• Molecular Weight: 254.24
• CAS Number: 480-40-0
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: ≥ 100 mg/ml (393.33 mM)
• Solution Preparation: 5mg added to 1.97ml DMSO, or 2.54mg added to 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

In Vitro Study

Chrysin, primarily found in passion flowers, honey, and propolis, acts as a potential therapeutic and preventive agent by inhibiting the proliferation and invasion of various human cancer cells. While Chrysin demonstrates anti-carcinogenic effects in several cancers, its functional roles in ovarian cancer, which exhibits poor prognosis and chemoresistance to traditional therapeutic agents, remain relatively unknown. Chrysin inhibits ovarian cancer cell proliferation and induces cell death by increasing reactive oxygen species (ROS) production and cytoplasmic Ca2+ levels, as well as by inducing loss of mitochondrial membrane potential (MMP). Concentration-response experiments reveal that Chrysin activates MAPK and PI3K/AKT pathways in ES2 and OV90 cells. Moreover, Chrysin suppresses tumor growth by regulating canonical Wnt and nuclear factor NF-κB signaling cascades in cancer cells. It also stimulates the phosphorylation of AKT and P70S6K proteins in both ES2 and OV90 cells compared to untreated control cells. Additionally, Chrysin activates phospho-ERK1/2, p38, and JNK proteins, members of the MAPK pathway, in ovarian cancer cells.

In Vivo Study

N/A

Clinical Trial

N/A

Storage

Store at -20°C for at least one year. The solid powder is stable at 4°C for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C for up to six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory