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Cat. No.: BTT-5 (for 5mg)

Cat. No.: BTT-25 (for 25mg)

Cat. No.: BTT-100 (for 100mg)

Chemical Information

• Chemical Name: Bestatin
• Abbreviation: Bestatin
• Synonyms: Ubenimex
• Chemical Formula: C16H24N2O4
• Molecular Weight: 308.37
• CAS Number: 58970-76-6
• Purity: 98%
• Solvent/Solubility: Water <1mg/ml; DMSO 6mg/ml; Ethanol <1mg/ml
• Solution Preparation: Dissolve 5mg in 1.62ml DMSO, or dissolve each 3.08mg in 1ml DMSO to prepare a 10mM solution. 

Biology Information

• Product Description: Bestatin is a competitive inhibitor of aminopeptidase B, acting on K562 cells with an IC50 of 100mg/ml.
• Signaling Pathway: Proteases
• Target: Aminopeptidase
• IC50: - 
• In Vitro Studies: Bestatin inhibits the proliferation of all human leukemia cell lines except KG1. In U937 cells, Bestatin induces DNA fragmentation and DNA ladder formation, as well as enhances caspase-3 activity. Bestatin dose-dependently induces DNA fragmentation in human leukemia cell lines. It inhibits the invasion of SN12M cells into reconstituted basement membrane (matrigel) in a concentration-dependent manner. Bestatin concentration-dependently inhibits the degradation of type IV collagen by tumor cells but not through tumor-conditioned medium (TCM). In SN12M cells, Bestatin inhibits substrate hydrolysis activity towards aminopeptidases. Bestatin inhibits tube formation in human umbilical vein endothelial cells (HUVECs). Bestatin exerts a direct stimulatory effect on lymphocytes (and monocytes) through leucine aminopeptidase anchored on the cell surface and an indirect effect on monocytes (lymphocytes) by inhibiting the breakdown metabolism of phagocytosis-promoting hormones by aminopeptidase B.
• In Vivo Studies: Bestatin significantly inhibits angiogenesis induced by melanoma cells as measured by mouse dorsal air sac assay. In the lateral side of the back of mice implanted with B16-BL6 melanoma cells, Bestatin reduces the number of established primary tumor blood vessels. In esophageal tissues of EGDA rats, Bestatin statistically significantly inhibits the biosynthesis of leukotriene B4. In EGDA rats, Bestatin reduces the incidence of EAC from 57.7% to 26.1%.

Precautions

• This product is for scientific research purposes only and is intended for use by professionals. It is not to be used for clinical diagnosis or treatment, and should not be used in food or drugs. It should not be stored in residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves when handling this product.

Storage

Store at room temperature, valid for at least 6 months. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C, expected to be valid for up to 6 months.

Only for research and not intended for treatment of humans or animals

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