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Cat. No.: ARCT-0.2 (for 10mM×0.2ml)

Cat. No.: ARCT-25 (for 25mg)

Cat. No.: ARCT-100 (for 100mg)

Description

Arctiin (NSC 315527), a plant lignan extractable from Arctium lappa (burdock) seeds, is a potential environmental endocrine disruptor compound. It has been demonstrated to affect sex hormone metabolism, protein synthesis, and steroid biosynthesis.

Basic Information

• Aliases: Arctii; NSC 315527; Arctigenin-4-glucoside
• Source: Arctium lappa L.
• Compound type: Phenylpropanoids > Lignans > Lignanins
• Chemical Formula: C₂₇H₃₄O₁₁
• Molecular Weight: 534.55
• CAS Number: 20362-31-6
• Purity: 98%, HPLC
• Solvent/Solubility: DMSO: 250 mg/ml (467.68 mM); Water: 10 mg/ml (18.71 mM; ultrasonic and warming and heat to 60°C)
• Solution Preparation: 10mg dissolved in 1.87ml DMSO, or 5.35mg per 1ml DMSO, to prepare a 10mM solution.

Signaling Pathway

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In Vitro Study

Treatment of PC-3 cells with arctiin resulted in a concentration- and time-dependent decrease in cell number under serum-containing conditions. Arctiin primarily induced cell detachment without exhibiting anti-proliferative or cytotoxic effects in PC-3 cells. The arctiin-induced effect was found to be inhibited by cycloheximide, suggesting a requirement for protein synthesis. While arctiin, the active component of AL described in the literature, did not reduce degranulation in RBL-2H3 cells, a single high-performance liquid chromatography (HPLC) fraction from the AL extract showed inhibition of beta-hexosaminidase release (IC50= 22.2 microg/ml). The growth inhibition attributed to arctiin is linked to the down-regulation of cyclin D1 protein expression. Moreover, the arctiin-induced suppression of cyclin D1 protein expression is observed across various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical, and breast cancer, melanoma, transformed renal cells, and prostate cancer. Depletion of the cyclin D1 protein using small interfering RNA rendered human breast cancer MCF-7 cells insensitive to the growth inhibitory effects of arctiin, implicating cyclin D1 as an important target of arctiin.

In Vivo Study

Histopathological evaluation of the prostate revealed that all rats in each group developed adenocarcinoma in the dorsolateral lobe of the prostate, except for two rats in the 0.1% arctiin-treated group and one rat in the 0.002% arctiin-treated group, which did not develop prostate adenocarcinoma. Following oral administration of arctiin (30, 60, 120 mg/kg/day) for three weeks, there was a significant decrease in the levels of serum creatinine (Scr) and blood urea nitrogen (BUN), as well as a marked reduction in 24-hour urine protein content, while the endogenous creatinine clearance rate (ECcr) significantly increased. STZ-induced diabetic rats were treated with arctiin at dosages of 60 or 40 mg/kg/day via intraperitoneal injection for 8 weeks. Blood glucose and 24-hour urinary albumin content were measured, and kidney histopathological changes were monitored.

Clinical Trial

N/A

Storage

Store at -20°C, effective for at least one year. Solid powder, store at 4°C, effective for at least one month. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C, expected to be effective for six months.

Precautions

• This product may have a certain degree of toxicity to the human body. Please take appropriate precautions to avoid direct contact with the body or inhalation.
• This product is for scientific research use only by professionals and is not intended for clinical diagnosis or treatment, food, or pharmaceutical purposes. It should not be stored in ordinary residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves while handling.

Only for research and not intended for treatment of humans or animals

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