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Cat. No.: APRO-5 (for 5mg)

Cat. No.: APRO-25 (for 25mg)

Cat. No.: APRO-100 (for 100mg)

Chemical Information

• Chemical Name: N/A
• Abbreviation: Aprotinin
• Synonyms: Trypsin Inhibitor; pancreatic basic; Trasylol
• Chemical Formula: C284H432N84O79S7
• Molecular Weight: 6511.44
• CAS Number: 9087-70-1
• Purity: 98%
• Solvent/Solubility: Water 100mg/ml
• Solution Preparation: Dissolve 5mg in 0.0768ml of water, or dissolve 65.11mg in 1ml of water to prepare a 10mM solution.

Biology Information

• Product Description: Aprotinin is a serine protease inhibitor that can inhibit pancreatic trypsin, pancreatic kallikrein, plasmin, and other serine proteases. It has a Kd of 0.06pM and 9.5nM for pancreatic trypsin and pancreatic kallikrein, respectively. It is used to reduce perioperative bleeding and transfusion.
• Signaling Pathway: Proteases
• Target: Thrombin, trypsin, kallikrein, chymotrypsin, trypsinogen
• IC50: －, 0.06pM (Kd), 0.8nM (Kd), 9.5nM (Kd), 2μM (Kd)
• In Vitro Studies: Aprotinin is a small molecule inhibitor of fibrinolysis that inhibits pancreatic trypsin and related proteinases. In cell biology, Aprotinin is used as a protease inhibitor to prevent protein degradation during tissue and cell homogenization and lysis. Aprotinin inhibits fibrinolysis in a dose-dependent manner and prolongs clotting time. In vitro, Aprotinin is an effective inhibitor of the endogenous coagulation pathway.
• In Vivo Studies: Aprotinin inhibits clot dissolution in vitro, prolongs tail bleeding time in rats, and extends clotting time in human plasma. In a rat arteriovenous shunt model, Aprotinin reduces thrombus weight.

Precautions

• This product is for scientific research purposes only and is intended for use by professionals. It is not to be used for clinical diagnosis or treatment, and should not be used in food or drugs. It should not be stored in residential areas.
• For your safety and health, please wear laboratory attire and disposable gloves when handling this product.

Storage

Store at room temperature, valid for at least 6 months. If dissolved in a non-DMSO solvent, it is recommended to aliquot and store at -80°C, expected to be valid for up to 6 months.

Only for research and not intended for treatment of humans or animals

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