Description

Research has found that Small Activating RNA (saRNA) can upregulate or activate the expression of target genes by acting on specific sequences of tumor suppressor gene promoters. This can inhibit the proliferation, invasion, and migration of cancer cells. The study of saRNA and RNAa's mechanisms of action provides feasible methods for the prevention or treatment of tumors, offering new perspectives for addressing major diseases like cancer. As a novel research tool, the mechanism of action of saRNA is complex. With more validated research data on saRNA, its mechanisms are gradually being elucidated. The designability, specificity, long-term effect, and versatility of saRNA make it more feasible to treat tumors by activating tumor suppressor gene expression. Currently, saRNA offers a new approach and broad clinical application prospects for the treatment of tumors and hereditary metabolic diseases.

Advantages

The activation of saRNA has a unique ability to enhance the transcription of target genes. Compared to traditional exogenous gene introduction, it has the following technical advantages:

• It can activate RNA for almost all target genes, restoring the natural function of genes.
• It anchors to the target gene initiation site and upstream promoter region, achieving persistent activation of target genes.
• It does not involve exogenous gene sequences, thereby not altering the genomic sequence information.

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SBS Genetech is a long-term sponsor of Cold Spring Harbor Laboratory