Description

Insulin-like growth factor-1 (IGF-1) is a hormone with a molecular weight of 9.1 kD, structurally similar to insulin. Its primary mechanism of action involves binding to its specific receptor (IGF1R), inducing intracellular signaling. IGF-1 is one of the most effective activators of the AKT signaling pathway, stimulating cell growth and proliferation while inhibiting apoptosis. IGF-1 LR3 is a modified form of IGF-1, created by adding 13 amino acids to the N-terminus of the complete IGF-1 molecule to form an 83-amino-acid long chain. Additionally, the third amino acid, glutamic acid (E), is replaced with arginine (R), hence the name R3. Compared to unmodified IGF-1, IGF-1 LR3 has greater stability and bioactivity.

Specifications

• Source: Escherichia coli
• Appearance: White lyophilized powder
• Purity: ≥90% (SDS-PAGE)
• Activity: ≥1.0×10^6 IU/mg
• pH: 6.5-7.5
• Molecular Weight: 9.1 kD
• Endotoxin: <5 EU/mg
• CAS No: 946870-92-4

Storage Conditions

• Storage: Store at -20°C
• Stability: Over 36 months

Precautions
Reconstitution: It is recommended to reconstitute rhIGF-1 LR3 lyophilized powder in sterile water to 100-200 µg/ml, with further dilution possible using other solvents. The reconstituted rhIGF-1 LR3 can be stored at 4°C for 2-7 days; use as soon as possible, and store at -20°C if not used shortly. Use promptly after opening to avoid contamination.

Usage Limitations
For research, laboratory, and production use only; not for direct human use.

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