Description

Alpha-1 antitrypsin (AAT) is a secretory protein produced by the liver and belongs to the serine protease inhibitor family. AAT protects tissues and organs from damage by inhibiting proteases, particularly neutrophil elastase. In the absence of adequate AAT, neutrophil elastase excessively hydrolyzes the elastic fibers in the alveolar walls, leading to respiratory complications such as emphysema and chronic obstructive pulmonary disease (COPD). AAT deficiency can also cause liver cell damage, resulting in cirrhosis. OsrhAAT is extracted from transgenic rice seeds, comprising 384 amino acids with a molecular weight of 46.7 kD.

Specifications

• Source: Rice seeds
• Appearance: White loose solid
• Purity: ≥90% (SDS-PAGE)
• Activity: ≥0.70 mg active AAT/mg total protein
• pH: 6.0-8.0
• Endotoxin: <1 EU/mg

Storage Conditions

• Storage: Store at -20°C
• Stability: Over 36 months

Precautions
Reconstitution: It is recommended to reconstitute OsrhAAT lyophilized powder in sterile PBS to 100-200 μg/ml, with further dilution possible using other solvents. The reconstituted OsrhAAT can be stored at 4°C for 2-7 days; if not used shortly, please store at -20°C.

Use promptly after opening to avoid contamination.

Usage Limitations
For research, laboratory, and production use only; not for direct human use.

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