On August 17th, a research paper entitled "Cellular Membrane-Engineered Nanovesicles as Three-Stage Booster to Target Lesion Core" was published in the prestigious academic journal Advanced Materials (impact factor: 32.086) by collaborated research group led by Professor Wei Jin, Professor Wenguo Cui and Professor Ke Yang from the School of Medicine at Shanghai Jiao Tong University.
This study introduces a novel nanocarrier, the Cellular Membrane-Engineered Nanovesicle (CMEV), for the treatment of ischemic cardiomyopathy. This nanocarrier is constructed using a double emulsion-extrusion method and has a hierarchical structure, integrating a neutrophil membrane, functional antibody, and gelled drug-loaded core as a 'three-stage booster' to target the lesion core and deliver Catestatin (CST), a small therapeutic peptide.
By coating the shell with a neutrophil membrane, the CMEV is endowed with the function of neutrophil-like migration to achieve the first stage of tissue targeting. Based on specific anchoring to injured myocardium, the Myosin Light Chain 3 (MLC3) antibody was embedded to fulfill the second stage of CMEV accumulation in the lesion core. The gelled core containing CST-sodium alginate (NaAlg) with a pH-responsive shell is prepared by ionic cross-linking to accomplish the third stage of precise CST administration. Triggered by the microenvironment, NaAlg electrostatically adheres to the lesion core for sustained release, enhancing the efficacy of CST in improving cardiomyocyte apoptosis, excessive fibrosis, macrophage polarization, and angiogenesis.
Thus, the "three-stage booster" nanovesicle significantly ameliorates cardiac function and adverse remodeling to treat ischemic cardiomyopathy. This research provides a novel and effective approach for treating ischemic cardiomyopathy.
In this research study, aqueous CST (6 mg/mL) is synthesized by SBS Genetech Co., Ltd.. Since 2000, SBS Genetech has been at the forefront of providing solutions in life sciences. We offer safer, superior quality, and more cost-effective products to preeminent researchers in nearly 60 countries, empowering them to make new discoveries in biology. Our products have been widely utilized in academic research, with results often published in leading academic journals like Science, Cell, Cancer Cell, and Cell Metabolism. We firmly believe that through continuous innovation and research, we will continually infuse new vitality and possibilities into the field of life sciences.